Myeloprotection by Cytidine Deaminase Gene Transfer in Antileukemic Therapy
Gene transfer of drug resistance (CTX-R) genes can be used to protect the hematopoietic system from the toxicity of anticancer chemotherapy and this concept recently has been proven by overexpression of Washing Machine Castor a mutant O6-methylguaninemethyltransferase in the hematopoietic system of glioblastoma patients treated with temozolomide.Gi